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- A deformable Brodmann area atlas
- Rasser, P. E.; Johnston, Patrick J.; Ward, Philip B.; Thompson, Paul M.
- Functional MRI studies commonly refer to activation patterns as being localized in specific Brodmann areas, referring to Brodmann's divisions of the human cortex based on cytoarchitectonic boundaries . Typically, Brodmann areas that match regions in the group averaged functional maps are estimated by eye, leading to inaccurate parcellations and significant error. To avoid this limitation, we developed a method using high-dimensional nonlinear registration to project the Brodmann areas onto individual 3D co-registered structural and functional MRI datasets, using an elastic deformation vector field in the cortical parameter space. Based on a sulcal pattern matching approach , an N=27 scan single subject atlas (the Colin Holmes atlas ) with associated Brodmann areas labeled on its surface, was deformed to match 3D cortical surface models generated from individual subjects' structural MRIs (sMRIs). The deformed Brodmann areas were used to quantify and localize functional MRI (fMRI) BOLD activation during the performance of the Tower of London task .
- Publication type
- Conference paper
- Proceedings of the 2nd IEEE International Symposium on Biomedical Imaging: Nano to Macro, Arlington, United States, 15-18 April 2004, Vol. 1, pp. 400-403
- Publication year
- Broadmann areas; Cerebral cortex; Deformation; Diagnostic group models; Elastic moduli; Magnetic resonance imaging; Mathematical transformations; Neurology; Pattern matching; Physiological models; Standardization
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