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Title

Advection-dispersion in symmetric field-flow fractionation channels

Author(s)

Suslov, Sergey A.;  Roberts, A. J.

Abstract

We model the evolution of the concentration field of macromolecules in a symmetric field-flow fractionation (FFF) channel by a one-dimensional advection-diffusion equation. The coefficients are precisely determined from the fluid dynamics. This model gives quantitative predictions of the time of elution of the molecules and the width in time of the concentration pulse. The model is rigorously supported by centre manifold theory. Errors of the derived model are quantified for improved predictions if necessary. The advection-diffusion equation is used to find that the optimal condition in a symmetric FFF for the separation of two species of molecules with similar diffusivities involves a high rate of cross-flow.

Publication type

Journal article

Source

Journal of Mathematical Chemistry, Vol. 26, no. 1-3 (Oct 1999), pp. 27-46

Publication year

1999

Keyword(s)

FFF;  Field flow fractionation

Publisher

Springer

ISSN

0259-9791

Publisher URL

http://dx.doi.org/10.1023/A:1019169408365

Copyright

Copyright © J.C. Baltzer AG, Science Publishers (1999). The author's revised version is reproduced in accordance with the copyright policy of the publisher. The definitive version is available at www.springer.com.

Full text

Peer reviewed