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Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.3/81184
- Dlg, Scribble and Lgl in cell polarity, cell proliferation and cancer
- Humbert, Patrick; Russell, Sarah; Richardson, Helena
- Dlg (Discs large), Scrib (Scribble) and Lgl (Lethal giant larvae) are evolutionarily conserved components of a common genetic pathway that link the seemingly disparate functions of cell polarity and cell proliferation in epithelial cells. dlg, scrib and lgl have been identified as tumour suppressor genes in Drosophila, mutations of which cause similar phenotypes, involving disruption of cell polarity and neoplastic overgrowth of tissues. The molecular mechanisms by which Dlg, Scrib and Lgl proteins regulate cell proliferation are not clear, but there is some evidence that epithelial polarisation is required for this regulation. Dlg, Scrib and Lgl are highly conserved between human and Drosophila, and we discuss evidence that these proteins also play a role in cancer progression in humans.
- Publication type
- Journal article
- BioEssays, Vol. 25, no. 6 (Jun 2003), pp. 542-553
- Publication year
- FOR Code(s)
- 06 Biological Sciences
- Cancer; Cell polarity; Cell proliferation; Discs large; Dlg; Drosophila; Lgl; Scribble; Tumour suppressors
- John Wiley & Sons
- Publisher URL
- Copyright 2003 Wiley Periodicals, Inc.
- Peer reviewed