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Home List of Titles Detergent-free caveolae proteome suggests an interaction with ER and mitochondria
Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.3/82100
- Detergent-free caveolae proteome suggests an interaction with ER and mitochondria
- McMahon, Kerrie-Ann; Zhu, Meifang; Kwon, Sung Won; Liu, Pingsheng; Zhao, Yingming; Anderson, Richard G. W.
- Recent proteomic studies of detergent resistant membrane fractions have begun to characterize the protein composition of caveolae and lipid rafts. The methods used in most of these studies, however, are not able to distinguish between plasma membrane and internal membrane lipid domains. Here we used a non-detergent method for obtaining fractions enriched in caveolae derived from the plasma membrane of multiple cell types. Unexpectedly, the proteins in the caveolae proteome suggest these lipid domains may interact with elements of ER and mitochondria. A comparison of the partial proteome we obtained with other published reports identifies 26 proteins that are candidate marker proteins for identifying caveolae in multiple cell types.
- Publication type
- Journal article
- Proteomics, Vol. 6, no. 1 (Jan 2006), pp. 143-152
- Publication year
- FOR Code(s)
- 0601 Biochemistry and Cell Biology
- Cell signaling; Endoplasmic reticulum; Lipid raft; Mass spectrometry; Membrane proteins
- WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
- Publisher URL
- Copyright © 2006 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
- Peer reviewed