Plasma-enhanced synthesis of bioactive polymeric coatings from monoterpene alcohols: a combined experimental and theoretical study

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Title: Plasma-enhanced synthesis of bioactive polymeric coatings from monoterpene alcohols: a combined experimental and theoretical study
Author(s): Bazaka, Kateryna; Jacob, Mohan V.; Truong, Vi Khanh; Wang, Feng; Pushpamali, Wickrama Arachchilage Anoja; Wang, James Y.; Ellis, Amanda V.; Berndt, Christopher C.; Crawford, Russell J.; Ivanova, Elena P.
Abstract: This paper describes the synthesis and characterization of a novel organic polymer coating for the prevention of the growth of Pseudomonas aeruginosa on the solid surface of three-dimensional objects. Substrata were encapsulated with polyterpenol thin films prepared from terpinen-4-ol using radio frequency plasma enhanced chemical vapor deposition. Terpinen-4-ol is a constituent of tea tree oil with known antibacterial properties. The influence of deposition power on the chemical structure, surface composition, and ultimately the antibacterial inhibitory activity of the resulting polyterpenol thin films was studied using X-ray photoelectron spectroscopy (XPS), water contact angle measurement, atomic force microscopy (AFM), and 3-D interactive visualization and statistical approximation of the topographic profiles. The experimental results were consistent with those predicted by molecular simulations. The extent of bacterial attachment and extracellular polymeric substances (EPS) production was analyzed using scanning electron microscopy (SEM) and confocal scanning laser microscopy (CSLM). Polyterpenol films deposited at lower power were particularly effective against P. aeruginosa due to the preservation of original terpinen-4-ol molecules in the film structure. The proposed antimicrobial and antifouling coating can be potentially integrated into medical and other clinically relevant devices to prevent bacterial growth and to minimize bacteria-associated adverse host responses.
Publication type: Journal article
Research centre: Swinburne University of Technology. Faculty of Life and Social Sciences
Research centre: Swinburne University of Technology. Faculty of Information and Communication Technologies. Centre for Molecular Simulation
Research centre: Swinburne University of Technology. Faculty of Engineering and Industrial Sciences. Industrial Research Institute Swinburne
Source: Biomacromolecules, Vol. 11, no. 8 (2010), pp. 2016-2026
Publication year: 2010
FOR Code(s): 03 Chemical Sciences; 06 Biological Sciences; 09 Engineering
Keyword(s): Atomic force microscopy; Bacterial growth prevention; Polymer coating; Pseudomonas aeruginosa; Terpinen-4-ol; X-ray photoelectron spectroscopy
Publisher: American Chemical Society
ISSN: 1525-7797
Publisher URL: http://dx.doi.org/10.1021/bm100369n
Additional information: This study was supported in part by Advanced Manufacturing Co-operative Research Centre (AMCRC); an Australian Postgraduate Award; an Australian Institute of Nuclear Science and Engineering Postgraduate Award (AINSE PGRA) and two Swinburne University Postgraduate Research Awards. The authors acknowledge funding and support from the Rural Industry Research and Development Corporation (RIRDC); the Department of Agriculture, Fisheries and Forestry of Australia (DAFF) as a part of Science and Innovation Award for Young. Supporting material for this paper is available at http://pubs.acs.org.
Peer reviewed