Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.3/92584

Title

Biomimetic modification of porous TiNbZr alloy scaffold for bone tissue engineering

Author(s)

Wang, Xiaojian;  Li, Yuncang;  Hodgson, Peter D.;  Wen, Cui'e

Abstract

Porous titanium (Ti) and Ti alloys are important scaffold materials for bone tissue engineering. In the present study, a new type of porous Ti alloy scaffold with biocompatible alloying elements, that is, niobium (Nb) and zirconium (Zr), was prepared by a space-holder sintering method. This porous TiNbZr scaffold with a porosity of 69% exhibits a mechanical strength of 67MPa and an elastic modulus of 3.9GPa, resembling the mechanical properties of cortical bone. To improve the osteoconductivity, a calcium phosphate (Ca/P) coating was applied to the surface of the scaffold using a biomimetic method. The biocompatibility of the porous TiNbZr alloy scaffold before and after the biomimetic modification was assessed using the SaOS2 osteoblast-like cells. Cell culture results indicated that the porous TiNbZr scaffold is more favorable for cell adhesion and proliferation than its solid counterpart. By applying a Ca/P coating, the cell proliferation rate on the Ca/P-coated scaffold was significantly improved. The results suggest that high-strength porous TiNbZr scaffolds with an appropriate osteoconductive coating could be potentially used for bone tissue engineering application.

Publication type

Journal article

Source

Tissue Engineering: Part A, Vol. 16, no. 1 (Jan 2010), pp. 309-316

Publication year

2010

FOR Code(s)

0601 Biochemistry and Cell Biology;  0903 Biomedical Engineering

Keyword(s)

Bone tissue engingeering;  Porous metals;  Scaffold;  Ti;  Ti alloys;  Titanium

Publisher

Mary Ann Liebert, Inc. Publishers

ISSN

1937-3341

Publisher URL

http://dx.doi.org/10.1089/ten.tea.2009.0074

Copyright

Copyright © Mary Ann Liebert, Inc.

Peer reviewed