Home List of Titles Biomimetic modification of porous TiNbZr alloy scaffold for bone tissue engineering
Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.3/92584
- Biomimetic modification of porous TiNbZr alloy scaffold for bone tissue engineering
- Wang, Xiaojian; Li, Yuncang; Hodgson, Peter D.; Wen, Cui'e
- Porous titanium (Ti) and Ti alloys are important scaffold materials for bone tissue engineering. In the present study, a new type of porous Ti alloy scaffold with biocompatible alloying elements, that is, niobium (Nb) and zirconium (Zr), was prepared by a space-holder sintering method. This porous TiNbZr scaffold with a porosity of 69% exhibits a mechanical strength of 67MPa and an elastic modulus of 3.9GPa, resembling the mechanical properties of cortical bone. To improve the osteoconductivity, a calcium phosphate (Ca/P) coating was applied to the surface of the scaffold using a biomimetic method. The biocompatibility of the porous TiNbZr alloy scaffold before and after the biomimetic modification was assessed using the SaOS2 osteoblast-like cells. Cell culture results indicated that the porous TiNbZr scaffold is more favorable for cell adhesion and proliferation than its solid counterpart. By applying a Ca/P coating, the cell proliferation rate on the Ca/P-coated scaffold was significantly improved. The results suggest that high-strength porous TiNbZr scaffolds with an appropriate osteoconductive coating could be potentially used for bone tissue engineering application.
- Publication type
- Journal article
- Tissue Engineering: Part A, Vol. 16, no. 1 (Jan 2010), pp. 309-316
- Publication year
- FOR Code(s)
- 0601 Biochemistry and Cell Biology; 0903 Biomedical Engineering
- Bone tissue engingeering; Porous metals; Scaffold; Ti; Ti alloys; Titanium
- Mary Ann Liebert, Inc. Publishers
- Publisher URL
- Copyright © Mary Ann Liebert, Inc.
- Peer reviewed