Evaluation of the long-term function of cryopreserved ovarian grafts in the mouse, implications for human applications

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Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.3/94557

Title: Evaluation of the long-term function of cryopreserved ovarian grafts in the mouse, implications for human applications
Author(s): Shaw, J. M.; Cox, S.-L.; Trounson, A. O.; Jenkin, G.
Abstract: Ovarian tissue storage has several potentially very valuable clinical applications, including the management of young female patients that are at risk of premature menopause. Ovarian tissue collection, used alone or in combination with oocyte and embryo cryopreservation, may help these patients safeguard their own future fertility. All available evidence from animal studies indicates that grafting of frozen ovarian tissue should be feasible in the human. This study on the mouse shows that frozen thawed ovarian tissue grafts can restore long term fertility to previously ovariectomised recipients. This, and other available evidence, indicates that ovarian tissue collection and storage, used alone or in combination with oocyte or embryo collection, may help safeguard the fertility of patients at risk of premature menopause.
Publication type: Journal article
Source: Molecular and Cellular Endocrinology, Vol. 161, no. 1-2 (Mar 2000), pp. 103-110
Publication year: 2000
FOR Code(s): 0601 Biochemistry and Cell Biology; 1103 Clinical Sciences
Keyword(s): Cryopreservation; Fertility; Grafting; Mice; Ovaries; Primordial follicles
Publisher: Elsevier
ISSN: 0303-7207
Publisher URL: http://dx.doi.org/10.1016/s0303-7207(99)00230-0
Peer reviewed