Surface plasmonic gold nanorods for enhanced two-photon microscopic imaging and apoptosis induction of cancer cells

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Surface plasmonic gold nanorods for enhanced two-photon microscopic imaging and apoptosis induction of cancer cells

Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.3/94592

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Title: Surface plasmonic gold nanorods for enhanced two-photon microscopic imaging and apoptosis induction of cancer cells
Author(s): Li, Jing-Liang; Gu, Min
Abstract: Two-photon microscopy powered by a femtosecond laser is a promising tool for luminescence imaging and localized microsurgery of cancers. However, the high energy required to destruct cells limits its medical applications. In this work, gold nanorods were conjugated with transferrin for efficient targeting, two-photon luminescence imaging and enhanced microsurgery of cancer cells. Due to the large two-photon excitation cross section of gold nanorods, gold nanorods are a hundred times more efficient than Fluorescein isothiocyanate (FITC), a common molecular dye, in three-dimensional imaging of cancer cells. The enhanced light absorption and energy conversion by gold nanorods enable treatment of cells with energy fluences two orders of magnitude below that in the absence of gold nanorods. By manipulating the energy fluence, apoptosis of cancer cells has been achieved. At a same power density, the energy fluence for apoptosis induction is less than 20% of that for necrosis. Gold nanorods-enhanced luminescence imaging coupled with apoptosis induction of cancer cells provides a medically safe femtosecond laser-based imaging and microsurgery system for cancer diagnosis and treatment.
Publication type: Journal article
Research centre: Swinburne University of Technology. Faculty of Engineering and Industrial Sciences. Centre for Micro-Photonics
Source: Biomaterials, Vol. 31, no. 36 (Dec 2010), pp. 9492-9498
Publication year: 2010
FOR Code(s): 0903 Biomedical Engineering; 0904 Chemical Engineering; 0912 Materials Engineering
Keyword(s): Apoptosis; Gold; Laser ablation; Nanoparticles; Surface modification
Publisher: Elsevier BV
ISSN: 0142-9612
Publisher URL: http://dx.doi.org/10.1016/j.biomaterials.2010.08.068
Peer reviewed