Evaluation of hematopoietic system effects after in vitro radiofrequency radiation exposure in rats

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Title: Evaluation of hematopoietic system effects after in vitro radiofrequency radiation exposure in rats
Author(s): Kumar, Gaurav; Wood, Andrew W.; Anderson, Vitas; McIntosh, Robert L.; Chen, Yuen Y.; Mckenzie,Ray J.
Abstract: Purpose:This study was designed to investigate the effect of a 900-MHz continuous-wave (CW) radiofrequency radiation (RFR) exposure on the hematopoietic system in the rat. Materials and methods:Rat long bones (femur and tibia) were divided into two groups: Sham-exposed and radiofrequency (RF)-exposed. The mean Specific energy Absorption Rate (SAR) at 900-MHz averaged over the bone marrow (calculated by the finite-difference-time-domain ( fdtD) method) was 2 W/kg at 16.7W root mean square (rms) forward power into a Transverse Electromagnetic (TEM) cell. The bones, placed in a Petri dish containing media, were kept in the TEM cell for 30min duration of sham or RF exposure. After exposure, the bone marrow cells were extracted and the following end points were tested: (a) Proliferation rate of whole bone marrow cells, (b) maturation rate of erythrocytes, (c) proliferation rate of lymphocytes, and (d) DNA damage (strand breaks/alkali labile sites) of lymphocytes. Results:Our data did not indicate any significant change in the proliferation rate of bone marrow cells and lymphocytes, erythrocyte maturation rate and DNA damage of lymphocytes. Conclusion:Our findings revealed no effect on the hematopoietic system in rats for 900 MHz CW RF exposure at the 2 W/kg localised SAR limit value recommended by the International Commission for Non-Ionising Radiation Protection (ICNIRP) for public exposures.
Publication type: Journal article
Research centre: Swinburne University of Technology. Faculty of Life and Social Sciences. Brain Sciences Institute
Source: International Journal of Radiation Biology, Vol. 87, no. 2 (Feb 2011), pp. 231-240
Publication year: 2011
FOR Code(s): 020302 Electrostatics and Electrodynamics; 110202 Haematology; 111705 Environmental and Occupational Health and Safety
Keyword(s): Bone marrow cells; DNA damage; RF radiation; TEM cell
Publisher: Informa Healthcare
ISSN: 0955-3002
Publisher URL: http://dx.doi.org/10.3109/09553002.2010.518212
Peer reviewed