Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.3/150047

Title

Mesoporous silica particles as templates for preparing enzyme-loaded biocompatible microcapsules

Author(s)

Yu, A.;  Wang, Y.;  Barlow, E.;  Caruso, F.

Abstract

An alternative, facile process for encapsulating biomacromolecules within polyelectrolyte microcapsules using mesoporous silica (MS) spheres as sacrificial templates for both enzyme immobilization and polyelectrolyte multilayer capsule formation, was reported. The encapsulation of of catalase in biocompatible poly(L-lysine) (PLL)/poly(L-glutamic acid) (PGA) was demonstrated. The activity of the catalase in the PLL/PGA microcapsules was examined by measuring the kinetics of hydrogen peroxide (H2O2) decomposition in a stirred system. The method yields microcapsules with high enzyme loading, retained enzyme activity, and enzyme in a free state.

Publication type

Journal article

Source

Advanced Materials, Vol. 17, no. 14 (Jul 2005), pp. 1737-1741

Publication year

2005

FOR Code(s)

0303 Macromolecular and Materials Chemistry;  0904 Chemical Engineering;  0912 Materials Engineering

Keyword(s)

Biocompatibility;  Biomaterials;  CLSM;  Confocal laser scanning microscopy;  Drug products;  Electrostatics;  Encapsulation;  Enzymes;  Hydrogen peroxide;  Macromolecules;  Mesoporous silica;  Multilayer films;  Pesticides;  Polyelectrolytes;  Silica;  Silica-core dissolution;  Transmission electron microscopy

Publisher

Wiley

ISSN

0935-9648

Publisher URL

http://dx.doi.org/10.1002/adma.200402045

Copyright

Copyright © 2005 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. The copyright policy of the publisher allows the accepted manuscript of the paper to be reproduced here after a publisher-imposed embargo period.

Peer reviewed