Electrochemical behavior of 6-mercapto-purine at hanging copper amalgam dropping electrode and its trace determination by differential pulse adsorption cathodic stripping voltammetry

Search Swinburne Research Bank

Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.3/150040

Title: Electrochemical behavior of 6-mercapto-purine at hanging copper amalgam dropping electrode and its trace determination by differential pulse adsorption cathodic stripping voltammetry
Author(s): Gu, Hai-Ying; Sun, Deng-Ming; Yu, Ai-Min; Chen, Hong-Yuan
Abstract: The electrochemical behavior of 6-MP was studied by cyclic voltammetry at a hanging copper amalgam dropping electrode (HCADE). It was found that 6-MP could form a complex with the Cu(II) stripped from the HCADE, showing a new peak at -0.19V in the medium of 0.1mol/L LiClO4-0.5mol/L HClO4 solution. The mechanism of the reaction was proposed. This new peak was sensitive and could be used for the determination of trace 6-MP by differential pulse adsorption cathodic stripping voltammetry (DPAdCSV). The linear range was from 3.6 x 10^-10 to 5.3 x 10^6 mol/L, and the detection limit was about 1.2 x 10^-10 mol/L (S/N=3). The method was also successfully applied to the determination of 6-MP in pharmaceutical tablets.
Publication type: Journal article
Source: Analytical Letters, Vol. 29, no. 15 (Dec 1996), pp. 2743-2753
Publication year: 1996
FOR Code(s): 0301 Analytical Chemistry
Keyword(s): 6-Mercaptopurine; Cathodic stripping; Differential pulse; Hanging copper amalgam electrode; Voltammetry
Publisher: Marcel Dekker (now an imprint of Taylor & Francis)
ISSN: 0003-2719
Publisher URL: http://dx.doi.org/10.1080/00032719608002277
Peer reviewed