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Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.3/153095
- Towards proteomics-on-chip: the role of the surface
- Salim, Malinda; McArthur, Sally L.; Vaidyanathan, S.; Wright, Phillip C.
- Miniaturisation is revolutionary to high-throughput proteomics. These technologies have gained much interest in the past decade, as they allow for sensitive parallel analysis of small amounts of biological materials. This review describes the state of the art of proteomics-on-chip, with a particular focus on the fundamental proteomics-on-chip challenges. The important role of bio-interfacial interactions and strategies to control them are presented. Various coating methodologies for on-chip protein/peptide separation are reviewed to provide an overview of the principles of protein-resistant and protein immobilisation coatings, and their effectiveness.
- Publication type
- Journal article
- Molecular Biosystems, Vol. 7, no. 1 (2011), pp. 101-115
- Publication year
- FOR Code(s)
- 0601 Biochemistry and Cell Biology
- Atomic-force microscopy; Capillary-zone-electrophoresis; Capacitively coupled microplasma; Chemical-analysis systems; Glycol dimethyl ether; Inner-wall; Linked-immunosorbent-assay; Plasma-polymerized films; Protein-resistant surfaces; Self-assembled monolayers
- Royal Society of Chemistry
- Publisher URL
- Copyright © 2011.
- Peer reviewed