Highly ordered nanometer-scale chemical and protein patterns by binary colloidal crystal lithography combined with plasma polymerization

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0904 Chemical Engineering | Kingshott, Peter

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Title: Highly ordered nanometer-scale chemical and protein patterns by binary colloidal crystal lithography combined with plasma polymerization
Author(s): Singh, Gurvinder; Griesser, Hans J.; Bremmell, Kristen; Kingshott, Peter
Abstract: Surfaces with micro- and nanometer-scale patterns have many potential applications, particularly in lifescience. This article reports on a versatile, straightforward, and inexpensive approach for the creation of chemical patterns using fabricated binary colloid crystals, consisting of small and large particles, as masks for the deposition of an amino-functionalised ultrathin film by plasma polymerization. After removal of the binary colloidal mask, the characterization techniques [scanning electron microscopy (SEM) and atomic force microscopy (AFM)] reveal a surface contrast that depicts an ability of the small particles to allow diffusion of the plasma to the substrate. A plasma-polymer film is created under the small particles and the region of substrate in direct contact with the large particle remains uncoated. Numerous types of patterns and feature heights can be produced with good fidelity over areas of several cm2 by appropriate tuning of the binary colloid crystal mask morphology and the plasma-polymer deposition time. Finally, the amine groups of the patterned surface are used for covalent grafting poly(ethylene glycol) propionaldehyde (PEG-PALD) by reductive amination under conditions of reduced solubility to produce a patterned surface for directed adsorption of protein. AFM investigations show that the proteins are preferentially attached to the nanometer-scale regions of the pattern without PEG-PALD. Binary colloidal crystal lithography integrated with plasma polymerization, a versatile approach, is developed to generate highly ordered chemical nanopatterned surfaces. Several types of 2D to 3D patterned surface have been fabricated over large areas by appropriately tuning the binary colloidal mask morphology. The amine groups of the patterned surface are activated to induce the covalent binding of poly(ethylene-glycol) molecules for specific protein adsorption.
Publication type: Journal article
Research centre: Swinburne University of Technology. Faculty of Engineering and Industrial Sciences
Source: Advanced Functional Materials, Vol. 21, no. 3 (Feb 2011), pp. 540-546
Publication year: 2011
FOR Code(s): 0303 Macromolecular and Materials Chemistry; 0904 Chemical Engineering; 0912 Materials Engineering
Keyword(s): Binary colloidal crystals; Lithography; Plasma polymerization; Protein nanopatterning; Self-assembly
Publisher: Wiley-VCH Verlag
ISSN: 1616-301X
Publisher URL: http://dx.doi.org/10.1002/adfm.201001340
Peer reviewed