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Title

The effect of polyterpenol thin film surfaces on bacterial viability and adhesion

Author(s)

Bazaka, Kateryna;  Jacob, Mohan V.;  Truong, Vi Khanh;  Crawford, Russell J.;  Ivanova, Elena P.

Abstract

The nanometer scale surface topography of a solid substrate is known to influence the extent of bacterial attachment and their subsequent proliferation to form biofilms. As an extension of our previous work on the development of a novel organic polymer coating for the prevention of growth of medically significant bacteria on three-dimensional solid surfaces, this study examines the effect of surface coating on the adhesion and proliferation tendencies of Staphylococcus aureus and compares to those previously investigated tendencies of Pseudomonas aeruginosa on similar coatings. Radio frequency plasma enhanced chemical vapor deposition was used to coat the surface of the substrate with thin film of terpinen-4-ol, a constituent of tea-tree oil known to inhibit the growth of a broad range of bacteria. The presence of the coating decreased the substrate surface roughness from approximately 2.1 nm to 0.4 nm. Similar to P. aeruginosa, S. aureus presented notably different patterns of attachment in response to the presence of the surface film, where the amount of attachment, extracellular polymeric substance production, and cell proliferation on the coated surface was found to be greatly reduced compared to that obtained on the unmodified surface. This work suggests that the antimicrobial and antifouling coating used in this study could be effectively integrated into medical and other clinically relevant devices to prevent bacterial growth and to minimize bacteria-associated adverse host responses.

Publication type

Journal article

Research centre

Swinburne University of Technology. Faculty of Life and Social Sciences

Source

Polymers, Vol. 3, no. 1 (2011), pp. 388-404

Publication year

2011

Keyword(s)

Nanoarchitecture;  Plasma polymerization;  Terpinen-4-ol

Publisher

MDPI Publishing

ISSN

2073-4360

Publisher URL

http://dx.doi.org/10.3390/polym3010388

Copyright

Copyright © 2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). The published version of the paper is reproduced here in accordance with this policy.

Additional information

The authors acknowledge support from the Advanced Manufacturing Co-operative Research Centre (AMCRC), Australian Postgraduate Award (APA), Australian Institute of Nuclear Science and Engineering Postgraduate Award (AINSE PGRA), the Rural Industry Research and Development Corporation (RIRDC), the Department of Agriculture, Fisheries and Forestry of Australia (DAFF) as a part of Science and Innovation Award for Young People in Agriculture, Fisheries and Forestry and the Swinburne University Postgraduate Research Award (SUPRA) award.

Full text

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