Search Swinburne Research Bank
Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.3/157559
- Dynamics of pulsatile flow in fractal models of vascular branching networks
- Bui, Anh; Sutalo, Ilija; Manasseh, Richard; Liffman, Kurt
- Efficient regulation of blood flow is critically important to the normal function of many organs, especially the brain. To investigate the circulation of blood in complex, multi-branching vascular networks, a computer model consisting of a virtual fractal model of the vasculature and a mathematical model describing the transport of blood has been developed. Although limited by some constraints, in particular, the use of simplistic, uniformly distributed model for cerebral vasculature and the omission of anastomosis, the proposed computer model was found to provide insights into blood circulation in the cerebral vascular branching network plus the physiological and pathological factors which may affect its functionality. The numerical study conducted on a model of the middle cerebral artery region signified the important effects of vessel compliance, blood viscosity variation as a function of the blood hematocrit, and flow velocity profile on the distributions of flow and pressure in the vascular network.
- Publication type
- Journal article
- Medical and Biological Engineering and Computing, Vol. 47, no. 7 (Jul 2009), pp. 763-772
- Publication year
- FOR Code(s)
- 0903 Biomedical Engineering
- Branching tree; Fractal models; Pulsatile flow; Vascular networks
- Publisher URL
- Copyright © International Federation for Medical and Biological Engineering 2009.
- Peer reviewed