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Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.3/189901
- Dilution media effects on proteinaceous ultrasound contrast agents
- de Souza-Daw, Tony; Chabaille, Christophe; Stewart, Robert; Manasseh, Richard; Junor, Paul; Bouakaz, Ayache
- The dilution effects of a protein solution and of water on the attenuation frequency spectrum of a proteinaceous ultrasound contrast agent were compared. The aim was to determine if the properties of the contrast agent changed when diluted in different media. The agent consists of microbubbles intended to be injected into blood, have shells made of a natural blood protein, Bovine Serum Albumin (BSA), and are air-filled. The effect of their dilution in both water and in a BSA concentration similar to blood was investigated. Attenuation frequency spectra of multiple, statistically averaged batches is plotted, with noticeable differences between the different dilution media of BSA and water. The attenuation relative to the dilution media was greater when the microbubbles were diluted in BSA than when diluted in water. The response in the BSA solution has a broader peak whereas water has relative statistically similar response for the 1-10 MHz frequency range. The difference in the responses was attributed to changes in the microbubble population caused by dilution in the different media.
- Publication type
- Conference paper
- Proceedings of the 2009 IEEE International Symposium on Bioelectronics and Bioinformatics (ISBB 2009), Melbourne, Australia, 09-11 December 2009 / Qiang Fang and Irena Cosic (eds.), pp. 45-48
- Publication year
- Bovine serum albumin; BSA; Dilution effects; Microbubbles; Proteinaceous ultrasound contrast agents
- School of Electrical and Computer Engineering, RMIT University
- 9780980731415, 0980731410
- Publisher URL
- Copyright © 2009 School of Electrical and Computer Engineering, RMIT.
- Peer reviewed