Asymmetric proteasome segregation as a mechanism for unequal partitioning of the transcription factor T-bet during T Lymphocyte division

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Title: Asymmetric proteasome segregation as a mechanism for unequal partitioning of the transcription factor T-bet during T Lymphocyte division
Author(s): Chang, John T.; Ciocca, Maria L.; Kinjyo, Ichiko; Palanivel, Vikram R.; McClurkin, Courtney E.; DeJong, Caitlin S.; Mooney, Erin C.; Kim, Jiyeon S.; Steinel, Natalie C.; Oliaro, Jane; Yin, Catherine C.; Florea, Bogdan I.; Overkleeft, Herman S.; Berg, Leslie J.; Russell, Sarah M.; Koretzky, Gary A.; Jordan, Martha S.; Reiner, Steven L.
Abstract: Polarized segregation of proteins in T-cells is thought to play a role in diverse cellular functions including signal transduction, migration, and directed secretion of cytokines. Persistence of this polarization can result in asymmetric segregation of fate-determining proteins during cell division, which may enable a T-cell to generate diverse progeny. Here, we provide evidence that a lineage-determining transcription factor, T-bet, underwent asymmetric organization in activated T-cells preparing to divide and that it was unequally partitioned into the two daughter cells. This unequal acquisition of T-bet appeared to result from its asymmetric destruction during mitosis by virtue of concomitant asymmetric segregation of the proteasome. These results suggest a mechanism by which a cell may unequally localize cellular activities during division, thereby imparting disparity in the abundance of cell fate regulators in the daughter cells.
Publication type: Journal article
Research centre: Swinburne University of Technology. Faculty of Engineering and Industrial Sciences. Centre for Micro-Photonics
Source: Immunity, Vol. 34, no. 4 (Apr 2011), pp. 492-504
Publication year: 2011
FOR Code(s): 1107 Immunology
Keyword(s): Asymmetric partitioning; Cell division; Polarization; Segregation; T cells; T Lymphocytes
Publisher: Cell Press
ISSN: 1074-7613
Publisher URL: http://dx.doi.org/10.1016/j.immuni.2011.03.017
Peer reviewed