Study of atomic force microscopy force-distance curves by simulation using the Connolly surface for proteins

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Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.3/2148

Title: Study of atomic force microscopy force-distance curves by simulation using the Connolly surface for proteins
Author(s): Cao, Jinan; Nicolau, Dan V.; Pham, Duy K.; Tonge, Livia Y.
Abstract: A simulation of the interaction between atomic force microscope tips and protein surfaces employing the concept of the Connolly molecular surface with a carbon probe has been investigated. A methodology has been developed to allow the computation of the Connolly surface for a protein, where numerous atoms are simultaneously interacting each other. The van derWaals and electrostatic interactions between the probe and the relevant Connolly surface elements are integrated to obtain the total interaction, resulting in precise theoretical accounts for a variety of interaction components.
Publication type: Journal article
Research centre: Swinburne University of Technology. Industrial Research Institute Swinburne
Source: Smart materials & structures, Vol. 11, no. 5 (2002), pp. 767-771 (5)
Publication year: 2002
Publisher: Institute of Physics Publishing
Format: pp. 767-771
ISSN: 0964-1726
Publisher URL: http://dx.doi.org/doi:10.1088/0964-1726/11/5/322
Peer reviewed