Molecular imaging of red blood cells by Raman spectroscopy

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Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.3/195006

Title: Molecular imaging of red blood cells by Raman spectroscopy
Author(s): Wood, Bayden R.; Stoddart, Paul R.; McNaughton, Donald
Abstract: Raman spectroscopy allows visualization of 2D and 3D chemical distributions at high spatial resolution in a wide range of samples. It is insensitive to water, which makes it particularly attractive for applications in the biological sciences. At the same time, technical advances have allowed the laser excitation power to be reduced on thermally sensitive samples, without sacrificing acquisition times. This review highlights the analytical and diagnostic potential of Raman imaging techniques by reference to recent studies of red blood cells. In the case of red blood cells infected with low-pigmented forms of the malaria parasite, molecular images reveal sub-micron-inclusions of haemozoin, which suggests that the technique has potential for early-stage diagnosis of the disease.
Publication type: Journal article
Research centre: Swinburne University of Technology. Faculty of Engineering and Industrial Sciences
Source: Australian Journal of Chemistry, Vol. 64, no. 5 (2011), pp. 593-599
Publication year: 2011
FOR Code(s): 03 Chemical Sciences
Keyword(s): Imaging techniques; Laser excitation; Malaria; Malaria parasite; Molecular imaging; Raman spectroscopy; Red blood cells
Publisher: CSIRO Publishing
ISSN: 0004-9425
Publisher URL: http://www.publish.csiro.au/nid/51/paper/CH11136.htm
Peer reviewed