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Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.3/195684
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- Scaling behavior of human locomotor activity amplitude: association with bipolar disorder
- Indic, Premananda; Salvatore, Paola; Maggini, Carlo; Ghidini, Stefano; Ferraro, Gabriella; Baldessarini, Ross J.; Murray, Greg
- Scale invariance is a feature of complex biological systems, and abnormality of multi-scale behaviour may serve as an indicator of pathology. The hypothalamic suprachiasmatic nucleus (SCN) is a major node in central neural networks responsible for regulating multi-scale behaviour in measures of human locomotor activity. SCN also is implicated in the pathophysiology of bipolar disorder (BD) or manic-depressive illness, a severe, episodic disorder of mood, cognition and behaviour. Here, we investigated scaling behaviour in actigraphically recorded human motility data for potential indicators of BD, particularly its manic phase. A proposed index of scaling behaviour (Vulnerability Index [VI]) derived from such data distinguished between: [i] healthy subjects at high versus low risk of mood disorders; [ii] currently clinically stable BD patients versus matched controls; and [iii] among clinical states in BD patients.
- Publication type
- Journal article
- Research centre
- Swinburne University of Technology. Faculty of Life and Social Sciences
- PLoS ONE, Vol. 6, no. 5 (May 2011), article no. e20650
- Publication year
- FOR Code(s)
- 07 Agricultural and Veterinary Sciences; 11 Medical and Health Sciences
- Bipolar disorder; Locomotor activity; Scaling behaviour
- Public Library of Science
- Publisher URL
- Copyright © 2011 Indic et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Additional information
- The authors acknowledge support from Swinburne University of Technology, Beyond Blue: National Depression Initiative, McLean Private Donors Bipolar Disorder Research Fund and a grant from the Bruce J Anderson Foundation.
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