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Title

Scaling behavior of human locomotor activity amplitude: association with bipolar disorder

Author(s)

Indic, Premananda;  Salvatore, Paola;  Maggini, Carlo;  Ghidini, Stefano;  Ferraro, Gabriella;  Baldessarini, Ross J.;  Murray, Greg

Abstract

Scale invariance is a feature of complex biological systems, and abnormality of multi-scale behaviour may serve as an indicator of pathology. The hypothalamic suprachiasmatic nucleus (SCN) is a major node in central neural networks responsible for regulating multi-scale behaviour in measures of human locomotor activity. SCN also is implicated in the pathophysiology of bipolar disorder (BD) or manic-depressive illness, a severe, episodic disorder of mood, cognition and behaviour. Here, we investigated scaling behaviour in actigraphically recorded human motility data for potential indicators of BD, particularly its manic phase. A proposed index of scaling behaviour (Vulnerability Index [VI]) derived from such data distinguished between: [i] healthy subjects at high versus low risk of mood disorders; [ii] currently clinically stable BD patients versus matched controls; and [iii] among clinical states in BD patients.

Publication type

Journal article

Research centre

Swinburne University of Technology. Faculty of Life and Social Sciences

Source

PLoS ONE, Vol. 6, no. 5 (May 2011), article no. e20650

Publication year

2011

FOR Code(s)

07 Agricultural and Veterinary Sciences;  11 Medical and Health Sciences

Keyword(s)

Bipolar disorder;  Locomotor activity;  Scaling behaviour

Publisher

Public Library of Science

ISSN

1932-6203

Publisher URL

http://dx.doi.org/10.1371/journal.pone.0020650

Copyright

Copyright © 2011 Indic et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Additional information

The authors acknowledge support from Swinburne University of Technology, Beyond Blue: National Depression Initiative, McLean Private Donors Bipolar Disorder Research Fund and a grant from the Bruce J Anderson Foundation.

Full text

Peer reviewed