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Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.3/2364
- Title
- Polymer microstructures for cellular growth studies
- Author(s)
- Filipponi, Luisa; Hanson, Kristi L.; Lee, Abraham P.; Nicolau, Dan V.
- Abstract
- The understanding and control of cell growth in confined microenvironments has application to a variety of fields including cell biosensor development, medical device fabrication, and pathogen control. While the majority of work in these areas has focused on mammalian and bacterial cell growth, this study reports on the growth behavior of fungal cells in three-dimensionally PDMS microenvironments of a scale similar to that of individual hyphae. Confinement was found to affect filament branching rate and angle. Overall, fungal hyphae demonstrate much more coordinated behavior during confinement than observed during growth on simple planar unconfined substrates. The remarkable difference of fungal growth behaviour observed in the PDMS microenvironments compared to open, unrestricted environments suggests that three-dimensional microstructures could be used to control and alter fungal motility.
- Publication type
- Conference paper
- Research centre
- Swinburne University of Technology. Faculty of Engineering and Industrial Sciences
- Source
- Proceedings of the Biomedical Applications of Micro- and Nanoengineering II, 13-15 December 2004, Sydney, New South Wales, Vol. 5651, pp. 45-51
- Publication year
- 2005
- Publisher
- SPIE
- ISBN
- 081945611X
- Publisher URL
- http://dx.doi.org/10.1117/12.584143
- Copyright
- ©2005 COPYRIGHT SPIE--The International Society for Optical Engineering.
- Peer reviewed
