Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.3/201748

Title

Surface modification and chemical surface analysis of biomaterials

Author(s)

Kingshott, Peter;  Andersson, Gunther;  McArthur, Sally L.;  Griesser, Hans J.

Abstract

The chemical composition of the surface layers of synthetic biomaterials used for human medical devices and in biotechnology plays a key role in determining interfacial interactions between biological media (such as protein solutions, cells, tissue) and the synthetic material. Accordingly, considerable research efforts focus on improving the 'biocompatibility' of biomaterials by applying various surface modification and thin film coating approaches. Here we focus on the patterning of surface chemistries, often designed to exercise spatial control over events such as cell attachment and spreading. Secondly, we review recent developments in chemical characterisation of biomaterials surfaces, which is essential both for verifying the success of intended surface modification strategies and for reliable interpretation of observed biological responses. Biomaterials surface analysis by imaging ToF-SIMS and XPS and compositional depth profiling are discussed, as is the emerging complementary technique of Metastable Induced Electron Spectroscopy.

Publication type

Journal article

Research centre

Swinburne University of Technology. Faculty of Engineering and Industrial Sciences. Industrial Research Institute Swinburne

Source

Current Opinion in Chemical Biology, Vol. 15, no. 5 (Oct 2011), pp. 667-676

Publication year

2011

FOR Code(s)

0304 Medicinal and Biomolecular Chemistry;  0601 Biochemistry and Cell Biology

Keyword(s)

Biomaterials;  Chemical composition;  Surface analysis;  Surface layers;  Surface modification

Publisher

Elsevier

ISSN

1367-5931

Publisher URL

http://dx.doi.org/10.1016/j.cbpa.2011.07.012

Copyright

Copyright © 2011 Elsevier Ltd. All rights reserved..

Peer reviewed