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Title

Mixed poly (ethylene glycol) (PEG) and oligo (ethylene glycol) (OEG) layers on gold as non fouling surfaces created by backfilling

Author(s)

Lokanathan, Arcot R.;  Zhang, Shuai;  Regina, Viduthalai R.;  Cole, Martin A.;  Ogaki, Ryosuke;  Dong, Mingdong;  Besenbacher, Flemming;  Meyer, Rikke L.;  Kingshott, Peter

Abstract

Backfilling a self-assembled monolayer (SAM) of long poly (ethylene glycol) (PEG) with short PEG is a well-known strategy to improve its potential to resist fouling. Here it is shown, using x-ray photoelectron spectroscopy, contact angle, and atomic force microscopy, that backfilling PEG thiol with oligo (ethylene glycol) (OEG) terminated alkane thiol molecules results in underbrush formation. The authors also confirm the absence of phase separated arrangement, which is commonly observed with backfilling experiments involving SAMs of short chain alkane thiol with long chain alkane thiol. Furthermore, it was found that OEG addition caused less PEG desorption when compared to alkane thiol. The ability of surface to resist fouling was tested through serum adsorption and bacterial adhesion studies. The authors demonstrate that the mixed monolayer with PEG and OEG is better than PEG at resisting protein adsorption and bacterial adhesion, and conclude that backfilling PEG with OEG resulting in the underbrush formation enhances the ability of PEG to resist fouling.

Publication type

Journal article

Research centre

Swinburne University of Technology. Faculty of Engineering and Industrial Sciences. Industrial Research Institute Swinburne

Source

Biointerphases, Vol. 6, no. 4 (Dec 2011), pp. 180-188

Publication year

2011

FOR Code(s)

0299 Other Physical Sciences;  0303 Macromolecular and Materials Chemistry

Keyword(s)

Backfilling;  Gold;  Non fouling surfaces;  Oligoethylene glycol;  Polyethylene glycol

Publisher

Springer

ISSN

1934-8630

Publisher URL

http://dx.doi.org/10.1116/1.3647506

Copyright

Copyright © 2011 American Vacuum Society. Published by SpringerOpen (http://www.springeropen.com/). This work is licensed under a Creative Commons Attribution (CC-BY) licence (http://creativecommons.org/licenses/by/2.0/). The published version is reproduced in accordance with this policy.

Additional information

The authors acknowledge support from the Danish Strategic Research Council (Grant No. 2106-07-0013), Alfa Laval, the Lundbeck Foundation, and the Carlsberg Foundation.

Full text

Peer reviewed