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Title

Microfluidic sensing: state of the art fabrication and detection techniques

Author(s)

Wu, Jing;  Gu, Min

Abstract

Here we introduce the existing fabrication techniques, detection methods, and related techniques for microfluidic sensing, with an emphasis on the detection techniques. A general survey and comparison of the fabrication techniques were given, including prototyping (hot embossing, inject molding, and soft lithography) and direct fabrication (laser micromachining, photolithography, lithography, and x-ray lithography) techniques. This is followed by an in-depth look at detection techniques: optical, electrochemical, mass spectrometry, as well as nuclear magnetic resonance spectroscopy-based sensing approaches and related techniques. In the end, we highlight several of the most important issues for future work on microfluidic sensing. This article aims at providing a tutorial review with both introductory materials and inspiring information on microfluidic fabrication and sensing for nonspecialists.

Publication type

Journal article

Research centre

Swinburne University of Technology. Faculty of Engineering and Industrial Sciences. Centre for Micro-Photonics

Source

Journal of Biomedical Optics, Vol. 16, no. 8 (Aug 2011), paper no. 080901

Publication year

2011

FOR Code(s)

0205 Optical Physics;  1113 Ophthalmology and Optometry

Keyword(s)

BioMEMS;  Biosensors;  Chemical sensors;  Electrochemical analysis;  Embossing;  Injection moulding;  Laser materials processing;  Mass spectroscopic chemical analysis;  Microfluidics;  Micromachining;  NMR spectroscopy;  Photolithography;  Soft lithography;  Spectrochemical analysis

Publisher

SPIE: International Society for Optical Engineering

ISSN

1083-3668

Publisher URL

http://dx.doi.org//10.1117/1.3607430

Copyright

Copyright © 2011 Society of Photo-Optical Instrumentation Engineers. This paper was originally published in Journal of Biomedical Optics (Vol. 16, no. 8), and is available from: http://dx.doi.org//10.1117/1.3607430. The published version of the paper is reproduced here in accordance with the copyright policy of the publisher. One print or electronic copy may be made for personal use only. Systematic electronic or print reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited.

Full text

Peer reviewed