Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.3/210090

Title

In vitro osteoblast-like cell proliferation on nano-hydroxyapatite coatings with different morphologies on a titanium-niobium shape memory alloy

Author(s)

Xiong, Jianyu;  Li, Yuncang;  Hodgson, Peter D.;  Wen, Cui'e

Abstract

The morphology of nanomaterials significantly affects their physical, chemical, and biological properties. In the present study, nano-hydroxyapatite coatings with different morphologies were produced on the surface of a titanium-niobium shape memory alloy via a hydrothermal process. The effect of the nano-hydroxyapatite coatings on the in vitro proliferation of SaOS-2 osteoblast-like cells was investigated. Factors including crystallinity, surface micro-roughness, and surface energy of the nano-hydroxyapatite coatings were discussed. Results show that in vitro proliferation of the osteoblast-like cells was significantly enhanced on the nano-hydroxyapatite-coated titanium-niobium alloy compared to the titanium niobium alloy without coating. The cell numbers on the nano-hydroxyapatite-coated titanium-niobium alloy changed consistently with the surface energy of the hydroxyapatite coatings. This study suggests that surface energy as a characteristic parameter influencing the in vitro proliferation of osteoblast-like cells was predominant over the crystallinity and surface micro-roughness of the nano-hydroxyapatite coatings.

Publication type

Journal article

Source

Journal of Biomedical Materials Research Part A, Vol. 95A, no. 3 (Dec 2010), pp. 766-773

Publication year

2010

FOR Code(s)

06 Biological Sciences;  09 Engineering

Keyword(s)

Hydrothermal process;  In vitro proliferation;  Nano-hydroxyapatite coating;  Osteoblast-like cells;  Titanium-niobium alloy

Publisher

John Wiley & Sons

ISSN

1552-4965

Publisher URL

http://dx.doi.org/10.1002/jbm.a.32903

Copyright

Copyright © 2010 Wiley Periodicals, Inc.

Peer reviewed