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Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.3/210400
- Melatonin sensitivity to dim white light in affective disorders
- Nathan, Pradeep J.; Burrows, Graham D.; Norman, Trevor R.
- Both dim and bright light has been shown to suppress the nocturnal secretion of the pineal hormone melatonin. Early reports suggests that an abnormal response to light occurs in patients with bipolar affective disorder, where as patients with major depressive disorder respond similarly to controls. It has been suggested that this abnormal sensitivity of the melatonin response to light could be a trait marker of bipolar affective disorder. However reports lack consistency. Hence, we investigated the melatonin suppression by dim light (200 lux) in patients with bipolar affective disorder, seasonal affective disorder and major depressive disorder. Results suggest that a supersensitive melatonin suppression to light in bipolar affective disorder (p < .005), and seasonal affective disorder (p < .05), whereas patients with major depressive disorder display similar suppression to controls. The supersensitivity may be a mechanism where by phase-delayed rhythms, are re-synchronised to a new circadian position. Conversely, an abnormality may exist in the pathway from the retina to the suprachiamatic nucleus.
- Publication type
- Journal article
- Research centre
- Swinburne University of Technology. Brain Sciences Institute
- Neuropsychopharmacology, Vol. 21, no. 3 (Sep 1999), pp. 408-413
- Publication year
- FOR Code(s)
- 11 Medical and Health Sciences; 17 Psychology and Cognitive Sciences
- Affective disorders; Affective neurosis; Biological markers; Bipolar affective disorder; Circadian rhythms; Depression; Light sensitivity; Melatonin; Supersensitivity; Suppression
- Nature Publishing Group
- Publisher URL
- Copyright © 1999 American College of Neuropsychopharmacology.
- Peer reviewed