This paper attempts to address some very important issues which came about with the opening of the branch campuses of well established and mature universities in different countries of Asia. The main problem faced by the staff and administration is ensuring equivalent teaching quality of the approved programs to the students. A few factors which may affect the quality are: the difference in staff maturity and mentorship, some cultural differences faced in regards with the quality assurance interaction process between intercampus academic staffs, the impossibility of duplicating the laboratory experiments, student cultural differences and exposure to different learning styles, and differences in assessment expectations. This paper considers the analysis of these factors and their influence on the program delivery quality. There is a discussion of the appropriate quality assurance process implementation, which can assure that the granted degrees are identical at any campus of the university.