Pharmacological properties of guggulsterones, the major active components of gum guggul

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Palombo, Enzo A.

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Pharmacological properties of guggulsterones, the major active components of gum guggul

Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.3/218441

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Title: Pharmacological properties of guggulsterones, the major active components of gum guggul
Author(s): Shah, Rohan; Gulati, Vandana; Palombo, Enzo A.
Abstract: Oleo gum resin secreted by Commiphora mukul, also known as gum guggul, has been used widely as an ayurvedic drug. Commiphora mukul is a short thorny shrub that is native to the Indian subcontinent. Oleo gum resin extracted by incision of the bark is a very complex mixture of gum, minerals, essential oils, terpenes, sterols, ferrulates, flavanones and sterones. Its active constituents, the Z- and E-guggulsterones, have been demonstrated to exhibit their biological activities by binding to nuclear receptors and modulating the expression of proteins involved in carcinogenic activities. Guggulsterones have also been reported to regulate gene expression by exhibiting control over other molecular targets including transcription factors such as nuclear factor (NF)-κB, signal transducer and activator of transcription (STAT) and steroid receptors. Considerable scientific evidence indicates the use of gum guggul as a therapeutic agent in the treatment of inflammation, nervous disorders, hyperlipidaemia and associated cardiac disorders such as hypertension and ischaemia, skin disorders, cancer and urinary disorders. This review highlights the taxonomic details, phytochemical properties and pharmacological profile of gum guggul.
Publication type: Journal article
Research centre: Swinburne University of Technology. Faculty of Life and Social Sciences. Environment and Biotechnology Centre
Source: Phytotherapy Research, Vol. 26, no. 11 (Nov 2012), pp. 1594-1605
Publication year: 2012
FOR Code(s): 03 Chemical Science; 06 Biological Sciences; 11 Medical and Health Sciences
Keyword(s): Commiphora mukul; Guggulsterones; Molecular targets; Oleo-gum; Pharmacological properties; Phytochemical properties
Publisher: John Wiley & Sons
ISSN: 0951-418X
Publisher URL: http://dx.doi.org/10.1002/ptr.4647
Peer reviewed