Classical microfluidic systems can be constructed in three major formats: microarray, droplet and continuous-flow systems. The format of construction is dictated by the intended practical application and therefore is dependent on the compatability between the non-biological and biological components of the microfluidic system. Understanding the physical aspects of microfluid dynamics is critical because in droplet-based and continuous-flow microfluidic systems, fluid surrounds and interacts with encapsulated respectively or nonencapsulated molecules. This review highlights the key requirements in the design and construction of droplet-based and continuous-flow microfluidic systems, and provides an overview of the respective roles played by the surface of the microfluidic device, its channel geometry, and the properties of the microfluids.
Advances in chemistry research, vol. 15 / James C. Taylor (ed.),
Chapter 1, pp. 1-30