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Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.3/227267
- Towards a protein vaccine for nontypeable Haemophilus influenzae
- Kyd, Jennelle M.; Cripps, Allan W.
- Nontypeable Haemophilus influenzae (NTHI), a gram-negative bacterium that is considered an important human pathogen, causes a broad spectrum of disease in both adults and children. An effective vaccine against NTHI would reduce the incidence of disease and reduce the dependency on antibiotic therapies as a means of defense. The results from immunization studies with whole killed-cell formulations of NTHI indicate that it is feasible to protect against NTHI infections by vaccination. The limitation of a whole-cell formulation is the considerable strain-heterogeneity in NTHI strains. Several proteins on the outer membrane appear highly conserved and offer potential as vaccine candidates.
- Publication type
- Journal article
- Clinical Infectious Diseases, Vol. 28, no. 2 (Feb 1999), p. 238
- Publication year
- FOR Code(s)
- 06 Biological Sciences; 11 Medical and Health Sciences
- Disease control; Haemophilus influenzae; Vaccines
- Oxford University Press
- Publisher URL
- Copyright © 1999 by the Infectious Diseases Society of America. All rights reserved.
- Peer reviewed