Towards a protein vaccine for nontypeable Haemophilus influenzae

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Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.3/227267

Title: Towards a protein vaccine for nontypeable Haemophilus influenzae
Author(s): Kyd, Jennelle M.; Cripps, Allan W.
Abstract: Nontypeable Haemophilus influenzae (NTHI), a gram-negative bacterium that is considered an important human pathogen, causes a broad spectrum of disease in both adults and children. An effective vaccine against NTHI would reduce the incidence of disease and reduce the dependency on antibiotic therapies as a means of defense. The results from immunization studies with whole killed-cell formulations of NTHI indicate that it is feasible to protect against NTHI infections by vaccination. The limitation of a whole-cell formulation is the considerable strain-heterogeneity in NTHI strains. Several proteins on the outer membrane appear highly conserved and offer potential as vaccine candidates.
Publication type: Journal article
Source: Clinical Infectious Diseases, Vol. 28, no. 2 (Feb 1999), p. 238
Publication year: 1999
FOR Code(s): 06 Biological Sciences; 11 Medical and Health Sciences
Keyword(s): Disease control; Haemophilus influenzae; Vaccines
Publisher: Oxford University Press
ISSN: 1058-4838
Publisher URL: http://dx.doi.org/10.1086/515119
Peer reviewed