Search Swinburne Research Bank
Home List of Titles Challenges for the development of vaccines against Haemophilus influenzae and Neisseria meningitidis
Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.3/227260
- Challenges for the development of vaccines against Haemophilus influenzae and Neisseria meningitidis
- Cripps, Allan W.; Foxwell, Ruth; Kyd, Jennelle
- The development of protein-polysaccharide conjugate vaccines has had a major impact on Haemophilus influenzae type b disease. The application of this technology to Neisseria meningitidis is also striking, particularly for serogroup C. However, significant challenges exist for the development of vaccines against non-typeable H. influenzae and against N. meningitidis serogroup B. Issues such as non-vaccine-strain replacement and correlates of protection need to be addressed as well as the longer-term implications of vaccination against what are essentially 'normal' microflora.
- Publication type
- Journal article
- Current Opinion in Immunology, Vol. 14, no. 5 (Oct 2002), pp. 553-557
- Publication year
- FOR Code(s)
- 1107 Immunology
- Antigens; Bacterial antigen; Bacterial meningitis; Diphtheria vaccine; Drug efficacy; Genetic variability; Genotype; Haemophilus influenzae; Haemophilus vaccines; Infection control; Influenza; Meningitis; Neisseria meningitidis; Outer membrane protein; Phenotype; Polysaccharide vaccine; Porins; Proteins; Serotype; Tetanus toxoid; Transferrin binding protein B; Vaccination; Vaccine production
- Publisher URL
- Copyright © 2002 Elsevier Science Ltd.
- Peer reviewed