Home List of Titles Challenges for the development of vaccines against Haemophilus influenzae and Neisseria meningitidis
Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.3/227260
- Challenges for the development of vaccines against Haemophilus influenzae and Neisseria meningitidis
- Cripps, Allan W.; Foxwell, Ruth; Kyd, Jennelle
- The development of protein-polysaccharide conjugate vaccines has had a major impact on Haemophilus influenzae type b disease. The application of this technology to Neisseria meningitidis is also striking, particularly for serogroup C. However, significant challenges exist for the development of vaccines against non-typeable H. influenzae and against N. meningitidis serogroup B. Issues such as non-vaccine-strain replacement and correlates of protection need to be addressed as well as the longer-term implications of vaccination against what are essentially 'normal' microflora.
- Publication type
- Journal article
- Current Opinion in Immunology, Vol. 14, no. 5 (Oct 2002), pp. 553-557
- Publication year
- FOR Code(s)
- 1107 Immunology
- Antigens; Bacterial antigen; Bacterial meningitis; Diphtheria vaccine; Drug efficacy; Genetic variability; Genotype; Haemophilus influenzae; Haemophilus vaccines; Infection control; Influenza; Meningitis; Neisseria meningitidis; Outer membrane protein; Phenotype; Polysaccharide vaccine; Porins; Proteins; Serotype; Tetanus toxoid; Transferrin binding protein B; Vaccination; Vaccine production
- Publisher URL
- Copyright © 2002 Elsevier Science Ltd.
- Peer reviewed