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Home List of Titles Deciduogenic effects of mediators of the polyphosphatidylinositol pathway in pseudopregnant mice
Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.3/227319
- Deciduogenic effects of mediators of the polyphosphatidylinositol pathway in pseudopregnant mice
- Kyd, J. M.; Murdoch, R. N.
- Intraluminal injections (15-mμ-l) of either concanavalin A (125-mμ-g) or ionophore A 23187 (0.01-mμ-mol) induce a decidual cell reaction (DCR) in the uterus of day 4.5 pseudopregnant mice. However, when these agents were administered in different combinations with each other or with CaCl2 (15-mμ-mol) and phorbol-12-myristate-13-acetate (1.6 nmol), interacting effects occurred to either enhance or inhibit each of the others' independent deciduogenic capacities. The results suggest that the polyphosphatidylinositol pathway and Ca^2+ are involved in the induction of the DCR in mice with complex interactions occurring between the active components of the pathway to modulate the outcome of the transformation process.
- Publication type
- Journal article
- Experientia, Vol. 48, no. 8 (Aug 1992), pp. 741-745
- Publication year
- Calcium ionophore; Concanavalin A; Decidualisation; Phorbol ester; Polyphosphatidylinositol pathway; Pseudopregnancy; Uterine biochemistry
- Birkhaeuser Verlag
- Publisher URL
- Copyright © Birkhaeuser Verlag Basel, 1992.
- Peer reviewed