Intraluminal injections (15-mμ-l) of either concanavalin A (125-mμ-g) or ionophore A 23187 (0.01-mμ-mol) induce a decidual cell reaction (DCR) in the uterus of day 4.5 pseudopregnant mice. However, when these agents were administered in different combinations with each other or with CaCl2 (15-mμ-mol) and phorbol-12-myristate-13-acetate (1.6 nmol), interacting effects occurred to either enhance or inhibit each of the others' independent deciduogenic capacities. The results suggest that the polyphosphatidylinositol pathway and Ca^2+ are involved in the induction of the DCR in mice with complex interactions occurring between the active components of the pathway to modulate the outcome of the transformation process.
Vol. 48, no. 8 (Aug 1992), pp. 741-745