Deciduogenic effects of mediators of the polyphosphatidylinositol pathway in pseudopregnant mice

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Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.3/227319

Title: Deciduogenic effects of mediators of the polyphosphatidylinositol pathway in pseudopregnant mice
Author(s): Kyd, J. M.; Murdoch, R. N.
Abstract: Intraluminal injections (15-mμ-l) of either concanavalin A (125-mμ-g) or ionophore A 23187 (0.01-mμ-mol) induce a decidual cell reaction (DCR) in the uterus of day 4.5 pseudopregnant mice. However, when these agents were administered in different combinations with each other or with CaCl2 (15-mμ-mol) and phorbol-12-myristate-13-acetate (1.6 nmol), interacting effects occurred to either enhance or inhibit each of the others' independent deciduogenic capacities. The results suggest that the polyphosphatidylinositol pathway and Ca^2+ are involved in the induction of the DCR in mice with complex interactions occurring between the active components of the pathway to modulate the outcome of the transformation process.
Publication type: Journal article
Source: Experientia, Vol. 48, no. 8 (Aug 1992), pp. 741-745
Publication year: 1992
Keyword(s): Calcium ionophore; Concanavalin A; Decidualisation; Phorbol ester; Polyphosphatidylinositol pathway; Pseudopregnancy; Uterine biochemistry
Publisher: Birkhaeuser Verlag
ISSN: 0014-4754
Publisher URL: http://dx.doi.org/10.1007/bf02124291
Peer reviewed