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Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.3/227348
- Airway bacterial interactions and impact on host immune responses
- Kyd, Jennelle; Krishnamurthy, Ajay; McGrath, John; Browne, Jessica; Vahedi, Fatemah
- The dynamic interactions of the major respiratory microbial pathogens are complex. An understanding of the impact on naturally acquired immune responses to respiratory polymicrobial commensal bacteria is slowly evolving. Maintaining a micro-floral balance and the host's ability to respond to imbalances associated with disease is critical. Studies of acquired immune responses have found that both antibody and cellular immune responses are suppressed by the presence of multiple bacteria when compared with colonization by the single microbe. Microbes interact with the mucosal epithelium through a range of receptor-ligand interactions, including interactions with Toll-like receptors and adhesion molecules. Regulation of the inflammatory response associated with commensal colonization suggests a possible role for Treg cells in controlling the upper airway responses to bacterial microflora with both bacteria-bacteria and bacteria-host interactions affecting colonization and immune responses.
- Publication type
- Book chapter
- Advances in oto-rhino-laryngology, vol. 72: Recent advances in tonsils and mucosal barriers of the upper airways / Yasuaki Harabuchi, Tatsuya Hayashi and Akihiro Katada (eds.), pp. 116-120
- Publication year
- Bacteria; Cellular immunity; Immunology; Inflammation; Mucosal immunity; Respiratory mucosa; Respiratory tract infections; Respiratory tract mucosa; Symbiosis
- 0065-3071 (series ISSN)
- 9783805597227, 3805597223
- Publisher URL
- Copyright © 2011 S. Karger AG, Basel.
- Peer reviewed