Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.3/227360

Title

Pulmonary immunity to Pseudomonas aeruginosa

Author(s)

Cripps, Allan W.;  Dunkley, Margaret L.;  Clancy, Robert L.;  Kyd, Jennelle

Abstract

Pseudomonas aeruginosa, an oportunistic bacterial pathogen, is a major course of morbidity and mortality in subjects with compromised respiratory function despite the significant advances in therapeutic practices. The bacteria produces an armoury. of products which modify its infective niche to ensure bacterial survival. The role of antibody in protection against pulmonary infection remains poorly defined. Protection appears to be associated with opsonizing antibody whilst some other antibody responses may be deleterious and promote further lung damage. Cell mediated responses are clearly important in protection against infection. This review proposes a vaccine strategy aimed at enhancing specific T cell responses in the lung which, through T cell-derived cytokines, drive the recruitment of neutrophils to the lung and the subsequent activation of these cells results in the clearance of bacteria from the lung.

Publication type

Journal article

Source

Immunology and Cell Biology, Vol. 73, no. 5 (Oct 1995), pp. 418-424

Publication year

1995

FOR Code(s)

0601 Biochemistry and Cell Biology;  1107 Immunology

Keyword(s)

Antibodies;  Antibody formation;  Bacterial pneumonia;  Cell mediated immunity;  Cellular immunity;  Immunisation;  Immunological models;  Inflammation mediators;  Lung;  Lymphocyte activation;  Pseudomonas aeruginosa;  Pseudomonas infections;  Respiratory tract infection;  T lymphocytes;  Vaccines

Publisher

Nature Publishing Group

ISSN

0818-9641

Publisher URL

http://dx.doi.org/10.1038/icb.1995.65

Copyright

Copyright © 1995.

Peer reviewed