Kinetics of inflammatory cytokines in the clearance of non-typeable Haemophilus influenzae from the lung

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Title: Kinetics of inflammatory cytokines in the clearance of non-typeable Haemophilus influenzae from the lung
Author(s): Foxwell, A. Ruth; Kyd, Jennelle M.; Cripps, Allan W.
Abstract: Levels of the pro-inflammatory cytokines TNF-α and IFN-γ were measured from the time of infection to the time of complete clearance of non-typeable Haemophilus influenzae (NTHi) from the lung in immune and non-immune rats. Mucosal immunization facilitated production of significant levels of TNF-α as early as 30 min post-pulmonary challenge with NTHi in immune animals. Following the peak at 2 h, rapid decline of TNF-α levels occurred from the alveolar spaces. Levels of TNF-α in non-immunized animals increased at a slower rate, peaked at a lower concentration and were slower to decline. The significantly larger number of macrophages seen in the immune animals at 1 h after bacterial challenge could partially account for the higher levels of TNF-α. Interferon-γ was not detected in immune or non-immune rats at any time point before NTHi clearance after pulmonary challenge. Study of the kinetics of TNF-α release demonstrates that immunized animals control the release of pro-inflammatory cytokines more effectively than non-immunized animals for enhanced clearance of bacterial infection from the lungs.
Publication type: Journal article
Source: Immunology and Cell Biology, Vol. 76, no. 6 (Dec 1998), pp. 556-559
Publication year: 1998
FOR Code(s): 0601 Biochemistry and Cell Biology; 1107 Immunology
Keyword(s): Bacteria; Bronchoalveolar lavage fluid; Cytokine production; Gamma interferon; Haemophilus infections; Haemophilus influenzae; IFN-gamma; Immunisation; Interferon Type II; Lung infection; Macrophage; Mucosal immunity; TNF-alpha; Tumor necrosis factor alpha; Vaccines
Publisher: Nature Publishing Group
ISSN: 0818-9641
Publisher URL: http://dx.doi.org/10.1046/j.1440-1711.1998.00771.x
Additional information: This research was supported by National Health and Medical Research Council grant number 951089.
Peer reviewed