Characteristics of the immunological response in the clearance of non- typeable Haemophilus influenzae from the lung

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Title: Characteristics of the immunological response in the clearance of non- typeable Haemophilus influenzae from the lung
Author(s): Foxwell, A. Ruth; Kyd, Jennelle M.; Cripps, Allan W.
Abstract: Clearance of non-typeable Haemophilus influenzae (NTHi) from the respiratory tract was investigated, over time, in immune and non-immune rats. A triphasic pattern characterized the clearance of bacteria from the lungs. Mucosal immunization enhanced bacterial clearance from the lungs in each of the three phases compared with clearance from non-immunized animals. Total clearance of bacteria was observed from lung tissue by 12 h in immune animals and 24 h in non-immune animals. Polymorphonuclear leucocytes not only arrived earlier and initially in greater numbers, but disappeared earlier in immune animals (peaking at 8 h post-challenge), compared with non-immune animals (peaking at 12h post-challenge). Systemically derived and locally produced NTHi-specific IgA and IgG correlated with enhanced bacterial clearance during the secondary phase. This model demonstrates that immunized animals up- regulate and resolve inflammatory responses to pulmonary infection more rapidly than the non-immunized controls.
Publication type: Journal article
Source: Immunology and Cell Biology, Vol. 76, no. 4 (Jul 1998), pp. 323-331
Publication year: 1998
FOR Code(s): 0601 Biochemistry and Cell Biology; 1107 Immunology
Keyword(s): Antibody production; Bacteria; Bacterial colonisation; Blood vessels; Bronchitis; Bronchoalveolar lavage fluid; Haemophilus infections; Haemophilus influenzae; Immune response; Inflammation; Leukocytes; Lung infection; Macrophage; Neutrophils; Phagocytosis; Polymorphs; Receptor upregulation; Vaccines
Publisher: Nature Publishing Group
ISSN: 0818-9641
Publisher URL: http://dx.doi.org/10.1046/j.1440-1711.1998.00740.x
Additional information: This research was supported by National Health and Medical Research Council grant number 951089.
Peer reviewed