CD8+ T cells have an essential role in pulmonary clearance of nontypeable Haemophilus influenzae following mucosal immunization

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Title: CD8+ T cells have an essential role in pulmonary clearance of nontypeable Haemophilus influenzae following mucosal immunization
Author(s): Foxwell, A. Ruth; Kyd, Jennelle M.; Karupiah, Guna; Cripps, Allan W.
Abstract: A rodent respiratory experimental model has proved useful for investigating the immune mechanisms responsible for clearance of bacteria from the lungs. Immunohistochemical studies in immune and nonimmune rats have identified the cellular kinetics of response to bacterial pulmonary infection for CD8+, CD4+, and γδ+ T cells; B cells; and the expression of major histocompatibility complex class II (MHC-II). During the course of bacterial clearance, there was no apparent proliferation or extravasation of lymphocytes, nor was there increased expression of MHC-II in nonimmune animals despite an influx of polymorphonuclear leukocytes, whereas in immunized animals there was an early influx of CD8+ and γδ+ T cells, followed by enhanced expression of the MHC-II marker, cellular infiltration by polymorphonuclear leukocytes, and finally an increased number of CD4+ T cells. Depletion of CD8+ T cells confirmed their vital contribution in the preprimed immune response to pulmonary infection by significantly decreasing the animals' ability to clear bacteria following challenge.
Publication type: Journal article
Source: Infection and Immunity, Vol. 69, no. 4 (Apr 2001), pp. 2636-2642
Publication year: 2001
FOR Code(s): 06 Biological Sciences; 07 Agricultural and Veterinary Sciences; 11 Medical and Health Sciences
Keyword(s): Antigen expression; B lymphocyte; CD4 antigen; CD8 antigen; Haemophilus influenzae; Immune response; Immunisation; Lung infection; Lymphocyte activation; Mucosal immunity; T lymphocytes
Publisher: American Society for Microbiology
ISSN: 0019-9567
Publisher URL: http://dx.doi.org/10.1128/iai.69.4.2636-2642.2001
Additional information: This research was supported by National Health and Medical Research Council grant number 951089.
Peer reviewed