Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.3/227472

Title

Nontypeable Haemophilus influenzae: challenges in developing a vaccine

Author(s)

Kyd, Jennelle;  Cripps, Allan

Abstract

Nontypeable Haemophilus influenzae (NTHi) is a gram-negative coccobacillus that is one of the bacteria that form the commensal flora of the upper respiratory tract in humans. This bacterium is an important human pathogen causing a broad spectrum of disease in both adults and children, including invasive and localised infections. The challenges in developing a bacterial protein antigen into an effective vaccine are, firstly, understanding what factors constitute an effective protective immune response for the host, and secondly, to design an effective delivery system that can target and induce the required immune response in humans that will prevent the variety of infections caused by NTHi. Copyright (C) 1999 Elsevier Science B.V. Nontypeable Haemophilus influenzae (NTHi) is a gram-negative coccobacillus that is one of the bacteria that form the commensal flora of the upper respiratory tract in humans. This bacterium is an important human pathogen causing a broad spectrum of disease in both adults and children, including invasive and localised infections. The challenges in developing a bacterial protein antigen into an effective vaccine are, firstly, understanding what factors constitute an effective protective immune response for the host, and secondly, to design an effective delivery system that can target and induce the required immune response in humans that will prevent the variety of infections caused by NTHi.

Publication type

Journal article

Source

Journal of Biotechnology, Vol. 73, no. 2-3 (Aug 1999), pp. 103-108

Publication year

1999

FOR Code(s)

06 Biological Sciences;  09 Engineering;  10 Technology

Keyword(s)

Antigens;  Bacteria;  Bacterial typing techniques;  Controlled drug delivery;  Delivery system;  Disease models;  Diseases;  Drug delivery systems;  Haemophilus influenzae;  Immune response;  Immunisation;  Negibacteria;  Outer membrane proteins;  Pathogenesis;  Protective immune response;  Proteins;  Vaccines

Publisher

Elsevier

ISSN

0168-1656

Publisher URL

http://dx.doi.org/10.1016/s0168-1656(99)00113-3

Copyright

Copyright © 1999 Elsevier Science B.V. All rights reserved.

Peer reviewed