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Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.3/227420
- A vaccine for nontypable Haemophilus influenzae
- Cripps, Allan W.; Kyd, Jennelle M.
- Nontypable H. influenzae (NTHI) is a common commensal of the upper respiratory tract residing in both the nasopharynx and the posterior oropharynx. It is one of the leading causative bacterial pathogens of otitis media (OM) in children and serious urogenital, neonatal and mother-infant infections. It is also the cause of significant morbidity in patients with pulmonary diseases such as cystic fibrosis and chronic obstructive pulmonary disease. NTHI colonizes the respiratory tract through adherence to the mucous and epithelial cells. It has several bacterial surface components that have the capacity to facilitate adherence and interactions between the bacterium and epithelial cells, setting the stage for the cycle of inflammation. Whole killed cell or bacterial extracts have been investigated in human trials providing results that demonstrate the potential for a vaccine to protect against infection. Several lead candidate antigens have been proposed based on studies in animal models but have yet to be formulated for human trials. The composition of a vaccine requires that the antigens be conserved among strains, immunogenic and protective against infection and that the delivery of the vaccine results in the relevant immune response, probably a balance of specific cellular and humoral responses.
- Publication type
- Book chapter
- Medical intelligence unit: New bacterial vaccines / Ronald W. Ellis and Bernard R. Brodeur (eds.), pp. 244-259
- Publication year
- Bacterial colonisation; Haemophilus influenzae; Respiratory tract infections; Vaccines
- 9780306478321, 0306478323
- Publisher URL
- Copyright © 2003 Eurekah.com and Kluwer Academic/Plenum Publishers.
- Peer reviewed