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Title

Modeling of light absorption in tissue during infrared neural stimulation

Author(s)

Thompson, Alexander C.;  Wade, Scott A.;  Brown, William G. A.;  Stoddart, Paul R.

Abstract

A Monte Carlo model has been developed to simulate light transport and absorption in neural tissue during infrared neural stimulation (INS). A range of fiber core sizes and numerical apertures are compared illustrating the advantages of using simulations when designing a light delivery system. A range of wavelengths, commonly used for INS, are also compared for stimulation of nerves in the cochlea, in terms of both the energy absorbed and the change in temperature due to a laser pulse. Modeling suggests that a fiber with core diameter of 200 μm and NA = 0.22 is optimal for optical stimulation in the geometry used and that temperature rises in the spiral ganglion neurons are as low as 0.1°C. The results show a need for more careful experimentation to allow different proposed mechanisms of INS to be distinguished.

Publication type

Journal article

Research centre

Swinburne University of Technology. Faculty of Engineering and Industrial Sciences

Source

Journal of Biomedical Optics, Vol. 17, no. 7 (Jul 2012), article no. 075002

Publication year

2012

FOR Code(s)

0205 Optical Physics;  0903 Biomedical Engineering;  1113 Ophthalmology and Optometry

Keyword(s)

Cochlear implant;  Laser;  Monte Carlo;  Optical stimulation;  Simulations

Publisher

SPIE

ISSN

1083-3668

Publisher URL

http://dx.doi.org/10.1117/1.JBO.17.7.075002

Copyright

Copyright © 2012 Society of Photo-Optical Instrumentation Engineers. This paper was originally published in Journal of Biomedical Optics (Vol. 17, no. 7), and is available from: http://dx.doi.org/10.1117/1.JBO.17.7.075002. The published version is reproduced in accordance with the copyright policy of the publisher. One print or electronic copy may be made for personal use only. Systematic electronic or print reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited.

Research Projects

Combined optical and electrical stimulation of auditory neurons, Australian Research Council grant number LP120100264

Full text

Peer reviewed