Home List of Titles A bacterial metapopulation adapts locally to phage predation despite global dispersal
Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.3/232635
- A bacterial metapopulation adapts locally to phage predation despite global dispersal
- Kunin, Victor; He, Shaomei; Warnecke, Falk; Peterson, S. Brook; Garcia Martin, Hector; Haynes, Matthew; Ivanova, Natalia; Blackall, Linda L.; Breitbart, Mya; Rohwer, Forest; McMahon, Katherine D.; Hugenholtz, Philip
- Using a combination of bacterial and phage-targeted metagenomics, we analyzed two geographically remote sludge bioreactors enriched in a single bacterial species Candidatus Accumulibacter phosphatis (CAP). We inferred unrestricted global movement of this species and identified aquatic ecosystems as the primary environmental reservoirs facilitating dispersal. Highly related and geographically remote CAP strains differed principally in genomic regions encoding phage defense mechanisms. We found that CAP populations were high density, clonal, and nonrecombining, providing natural targets for 'kill-the-winner' phage predation. Community expression analysis demonstrated that phages were consistently active in the bioreactor community. Genomic signatures linking CAP to past phage exposures were observed mostly between local phage and host. We conclude that CAP strains disperse globally but must adapt to phage predation pressure locally.
- Publication type
- Journal article
- Genome Research, Vol. 18, no. 2 (Feb 2008), pp. 293-297
- Publication year
- FOR Code(s)
- 06 Biological Sciences; 11 Medical and Health Sciences
- Accumulibacter phosphatis; Bacteriophages; Betaproteobacteria; Biological adaptation; Candidatus accumulibacter phsophatis; Evolutionary adaptation; Gene expression profiling; Microarray analysis; Phagocytosis; Phylogeny; Queensland; Sewage; Sludge; Wisconsin
- Cold Spring Harbor Laboratory Press
- Publisher URL
- Copyright © 2008 Cold Spring Harbor Laboratory Press. This article is freely available online through the Genome Research Open Access option.
- Peer reviewed