Home List of Titles Association between apolipoprotein E polymorphisms and age-related macular degeneration: a HuGE review and meta-analysis
Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.3/233143
- Association between apolipoprotein E polymorphisms and age-related macular degeneration: a HuGE review and meta-analysis
- Thakkinstian, Ammarin; Bowe, Steve; McEvoy, Mark; Smith, Wayne; Attia, John
- A possible association between apolipoprotein E polymorphisms and age-related macular degeneration has been investigated numerous times, with conflicting results. A previous analysis pooling results from four studies (Schmidt et al., Ophthalmic Genet 2002;23:209-23) suggested an association, but those investigators did not document allele frequencies, the magnitude of the association, or the possible genetic mode of action. Thus, the authors searched MEDLINE from 1966 to December 2005 for any English-language studies reporting genetic associations. Data and study quality were assessed in duplicate. Pooling was performed while checking for heterogeneity and publication bias. Frequencies of the E2 and E4 alleles in Caucasians were approximately 8% and 15%, respectively. Allele- and genotype-based tests of association indicated a risk effect of up to 20% for E2 and a protective effect of up to 40% for E4. E2 appeared to act in a recessive mode and E4 in a dominant mode. There appears to be a differential effect of the E2 and E4 alleles on the risk of age-related macular degeneration, although the possibility of survivor bias needs to be ruled out more definitively.
- Publication type
- Journal article
- American Journal of Epidemiology, Vol. 164, no. 9 (Nov 2006), pp. 813-822
- Publication year
- FOR Code(s)
- 01 Mathematical Sciences; 11 Medical and Health Sciences
- Alleles; ApoE; Apolipoproteins E; Asian continental ancestry group; Demography; Disease association; Epidemiology; European continental ancestry group; Gene frequency; Genetics; Genotype; Macular degeneration; Meta analysis; Polymorphism; Protein polymorphism; Retina macula age related degeneration; Systematic review
- Oxford University Press
- Publisher URL
- Copyright © 2006 by the Johns Hopkins Bloomberg School of Public Health. All rights reserved.
- Peer reviewed