The effect of corruption in South Africa has seriously constrained development of the national economy and has significantly inhibited good governance in the country. South Africa's complex political design is a contributing factor to the rise of corruption, which has adversely affected stability and trust and which has damaged the ethos of democratic values and principles. Although the South African government has been instrumental in systems to fight the evils of corruption, practical problems have increasingly emerged over the years. The most notable problems are: insufficient coordination of anti-corruption work within the South African public service and among the various sectors of society; poor information about corruption and the impact of anti-corruption measures and agencies; and the impact of corruption on good governance. This paper is a part of a broader study undertaken on corruption. It addresses issues related to corruption and good governance in the South African (National) Public Service. To articulate and analyse the challenges confronting the country, issues regarding coordination of anti-corruption agencies will be explored.