A database comprising biomolecular descriptors relevant to protein adsorption on microarray surfaces

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Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.3/4246

Title: A database comprising biomolecular descriptors relevant to protein adsorption on microarray surfaces
Author(s): Nicolau, Dan V. Jr; Nicolau, Dan V.
Abstract: The adsorption of biomolecules on surfaces is dependent on biomolecule molecular descriptors, surface descriptors and environment descriptors. Of these descriptors, the biomolecular-related are the most complex and arguably the most important, as being related to both adsorption and possible denaturation on surfaces. The criticality of biomolecule adsorption in the context of microarrays and microfluidics devices will increase with the advancement of proteomics that probes the functionality of proteins, which are much more responsive to surfaces than DNA - the focal biomolecule of genomics. Anticipating this development, the present contribution proposes the establishment of a biomolecular descriptors database, which could be the starting point for a depositary of data and a source of validation for predictive models for adsorption and denaturation.
Publication type: Conference paper
Research centre: Swinburne University of Technology. Industrial Research Institute Swinburne
Source: [Proceedings], Biomedical Nanotechnology Architectures and Applications, San Jose, California, USA, 20-24 January 2002
Publication year: 2002
Publisher: SPIE - International Society for Optical Engineering
Format: pp. 109-115
Publisher URL: http://dx.doi.org/10.1117/12.472070