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Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.3/4247
- A model of protein adsorption to solid surfaces from solution
- Nicolau, Dan V. Jr; Nicolau, Dan V.
- The absorption of biomolecules on surfaces is a perennial and general problem relevant to fields as different as biomaterials, biosensors, microarrays for proteomics and microfluidics. The 'responsiveness-to-surfaces' character of the proteins augments the difficulty of the general problem of biomolecule adsorption on surfaces. This complexity of protein adsorption generated a large number of contributions over the years, with a rate not showing signs of slowing down. This contribution proposes the use of existent data, as well as data generated in 'programmatic', factorial experiments, to generate scaling relationships regarding protein attachment on polymer surfaces linking protein molecular descriptors, surface descriptors and solution descriptors in a common, quasi-empirical 'engineering' relationships. These relationships can be used for the design of surfaces for proteomics microarrays and microfluidic devices.
- Publication type
- Conference paper
- Research centre
- Swinburne University of Technology. Industrial Research Institute Swinburne
- [Proceedings], Biomedical Nanotechnology Architectures and Applications, San Jose, California, USA, 20-24 January 2002
- Publication year
- SPIE - International Society for Optical Engineering
- pp. 1-8
- Publisher URL
- ©2003 COPYRIGHT SPIE--The International Society for Optical Engineering