Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.3/5081

Title

Gamma and beta frequency oscillations in response to novel auditory stimuli: a comparison of human electroencephalogram (EEG) data with in vitro models

Author(s)

Haenschel, Corinna;  Baldeweg, Torsten;  Croft, Rodney J.;  Whittington, Miles;  Gruzelier, John H.

Abstract

Investigations using hippocampal slices maintained in vitro have demonstrated that bursts of oscillatory field potentials in the gamma frequency range (30-80 Hz) are followed by a slower oscillation in the beta 1 range (12-20 Hz). In this study, we demonstrate that a comparable gamma-to-beta transition is seen in the human electroencephalogram (EEG) in response to novel auditory stimuli. Correlations between gamma and beta 1 activity revealed a high degree of interdependence of synchronized oscillations in these bands in the human EEG. Evoked (stimulus-locked) gamma oscillations preceded beta 1 oscillations in response to novel stimuli, suggesting that this may be analogous to the gamma-to-beta shift observed in vitro. Beta 1 oscillations were the earliest discriminatory responses to show enhancement to novel stimuli, preceding changes in the broad-band event-related potential (mismatch negativity). Later peaks of induced beta activity over the parietal cortex were always accompanied by an underlying gamma frequency oscillation as seen in vitro. A further analogy between in vitro and human recordings was that both gamma and beta oscillations habituated markedly after the initial novel stimulus presentation.

Publication type

Journal article

Source

Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, no. 13 (Jun 2000), pp. 7645-7650

Publication year

2000

ISSN

1091-6490

Publisher URL

http://dx.doi.org/10.1073/pnas.120162397

Copyright

Copyright © 2000 National Academy of Sciences.

Peer reviewed