Direct evidence that acutely enhancing serotonin with the selective serotonin reuptake inhibitor citalopram modulates the loudness dependence of the auditory evoked potential (LDAEP) marker of central serotonin function

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Title: Direct evidence that acutely enhancing serotonin with the selective serotonin reuptake inhibitor citalopram modulates the loudness dependence of the auditory evoked potential (LDAEP) marker of central serotonin function
Author(s): Nathan, Pradeep J.; Segrave, Rebecca; Phan, K. Luan; O'Neill, Barry V.; Croft, Rodney J.
Abstract: The loudness dependence of the auditory evoked potential (LDAEP) has been suggested as a reliable measure of central serotonin function in humans. The most convincing evidence for a direct relationship between serotonergic function and LDAEP to date has come from animal studies, while evidence in humans has been circumstantial and inconsistent. In the current study, we examine the direct effect of serotonergic modulation with the selective serotonin reuptake inhibitor (SSRI) citalopram on the LDAEP. The study was a double-blind placebo controlled design in which healthy participants were tested under two acute treatment conditions: placebo and citalopram (20 mg). Enhancement of serotonin function with citalopram in comparison to placebo decreased the slope of the LDAEP (i.e. weaker LDAEP). The findings provide direct evidence in humans, of a relationship between central serotonin function and the LDAEP, supporting findings previously observed in animals and clinical populations. Together the results provide further support for the validity of the LDAEP as a non-invasive in vivo measure of central serotonin function in humans.
Publication type: Journal article
Research centre: Swinburne University of Technology. Faculty of Life and Social Sciences. Brain Sciences Institute
Source: Human Psychopharmacology: Clinical and Experimental, Vol. 21, no. 1 (2006), p. 47-52
Publication year: 2006
Keyword(s): Biological marker; Citalopram; Electrophysiology; Event related potential; LDAEP; Loudness dependence auditory evoked potential; Selective serotonin reuptake inhibitor; Serotonin
Publisher: John Wiley & Sons
ISSN: 0885-6222
Publisher URL: http://dx.doi.org/10.1002/hup.740
Copyright: Copyright © 2005 John Wiley & Sons, Ltd. Publisher does not officially support author/institution self-archiving of either the postprint (final, revised accepted draft) or published version of full text.
Peer reviewed