Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.3/5459

Title

Compartmentalization in T-cell signalling : membrane microdomains and polarity orchestrate signalling and morphology

Author(s)

Russell, Sarah;  Oliaro, Jane

Abstract

Lymphocyte function is regulated by complex signalling responses to diverse extracellular inputs, and a cell will often receive multiple, conflicting signals at one time. The mechanisms by which a lymphocyte integrates these signals into a single cellular response are not well understood. An important factor in the integration of signals likely involves the regulation of access of signalling molecules to cell surface receptors and of receptor signals to morphological determinants within the cell. Recent studies have led to important advances in our understanding of both the mechanisms by which signals are compartmentalized in T cells and the physiological role played by such compartmentalization. We review progress in the field, with a particular focus on membrane microdomains or lipid rafts and on cell polarity.

Publication type

Journal article

Research centre

Swinburne University of Technology. Faculty of Engineering and Industrial Sciences. Centre for Micro-Photonics

Source

Immunology and Cell Biology, Vol. 84, no. 1 (2006), p. 107-113

Publication year

2006

Keyword(s)

Cell polarity;  Immunological synapse;  Lipid rafts;  Scribble

Publisher

Blackwell Publishing

Format

107-113

ISSN

0818-9641

Publisher URL

http://dx.doi.org/10.1111/j.1440-1711.2005.01415.x

Copyright

Copyright © 2006 Australasian Society for Immunology Inc.

Peer reviewed